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Alphabetical Index
ALPHA-FETOPROTEIN, Maternal Serum (8000100330)
Test Mnemonic:

AFP-MS1 
Specimen Requirements:
Collection:

:  7 mL of blood in SST (gold top) tube or red stoppered tube. When screening for neural tube defect and Down Syndrome, a 'Patient Information Form for AFP Testing' must be completed - includes age, race, weight, insulin dependence, and gestation age.
Minimum Volume:

3 mL
Storage/Transport:

 

Delivered to Sample Management within 2 hours of collection.
Stability:

Store samples tightly stoppered at room temperature   for no longer than eight hours;  Refrigerated  for 48 hours; Freeze at -20°C or colder (avoid repeated freeze/thaw cycles).
Causes for Rejection:

Incomplete and/or incorrect sample identification, improper storage/transport, and gross hemolysis or lipemia.            
Specimen Preparation:

Allow specimen to clot completely at room temperature. Centrifuge to separate serum from cells within 2 hours of collection. Transfer serum from collection tube to labeled plastic transport tube. 
Methodology:

Immunoenzymatic
Performed:

Monday – Friday:  7 am – 3:30 pm
Lab:

Special Chemistry
Turnaround Time:

  M-F: within 24 hours
Reference Range:

By report (reports may vary based on instrumentation, patient age and sex).
CPT 4 Code:

82105, 84702, 82677
Note:

Blood should be drawn before amniocentesis. Not available on Week-ends
Patient Preparation :

Patient must be in the 2nd Trimester of pregnancy (within 15 weeks, 0 days and 20weeks, 6 days).

 

Patient must be in the 2nd Trimester of pregnancy (within 15 weeks, 0 days and 20weeks, 6 days).
Clinical Indication:

Screening test for neural tube defects (anencephaly, spina bifida) and Down Syndrome of the fetus in pregnant women between 14 and 21 weeks gestation. For use as a tumor marker, see Alpha-Fetoprotein, serum.   
Effective Date: 03/01/2013
Reviewed By/Date: Okorodudu, Anthony - 02/17/2019
Approved By/Date: Okorodudu, Anthony - 12/20/2022
When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.

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