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Kappa Lambda Free Light Chains w/ Ratio, Serum (8000101669)
Test Mnemonic:

KLFLC
Specimen Requirements:
Test Included:

Kappa Free Light Chains

Lambda Free Light Chains

Kappa/Lambda Ratio

 
Collection:

Routine Collection.  Only serum samples can be used for Kappa and Lambda Free Ligh Chain Assays.
Container:

SST, Red Top
Minimum Volume:

3 ml
Storage/Transport:

Deliver to Sample Management within 2 hours if unspun.
Stability:

Samples stored at 2-8°C are stable for 21 days; longer storage should be kept at -20°C. Repeated freeze/thaw cycles should be avoided to minimize potential protein degradation.
Causes for Rejection:

Incomplete and/or incorrect sample identification, improper storage/transport specimen should be rejected.

Severely turbid samples should not be used.

 
Specimen Preparation:

Specimens should be centrifuged and serum removed from the clot within 2 hours of collection. Pour over the serum from the red top into a plastic transfer vial and cap.  If collected in an SST tube, the specimen can be stored in the collection device after centrifugation.
Methodology:

Latex enhanced immunoturbidimetric.
Performed:
Lab:

Galveston Clinical Chemistry
Turnaround Time:

Routine turnaround time is 8 hours.

STAT turnaround time is 1 hour.

 
Reference Range:

Kappa Free Light Chain: 2.37-20.73 mg/L

Lambda Free Light Chain: 4.23-27.69 mg/L

Kappa/Lambda Ratio: 0.22 - 1.74

 
CPT 4 Code:

83521
Synonyms:

Kappa, Qnt, Free, Light Chains, Lambda
Patient Preparation :

None.
Clinical Indication:

The measurement of Kappa FLC in conjunction with Lambda FLC aids in the evaluation and management of multiple myeloma and other related plasma cell disorders.
Effective Date: 04/02/2024
Reviewed By/Date: -
Approved By/Date: Okorodudu, Anthony - 04/02/2024
When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.

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