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Alphabetical Index
Anti-Chromatin Antibody (8000100936)
Test Mnemonic:
Specimen Requirements:
Collection:

Serum separator tube (SST) or Red top serum tube with no additive
Container:

Serum separator tube (SST) or Red top serum tube with no additive
Minimum Volume:

3 mL of blood (1mL of serum)
Storage/Transport:

Refrigerate (2-8°C) up to 7 days; Samples should be frozen (<-20°C)
Stability:

Refrigerate (2-8°C) up to 7 days; Samples should be frozen (<-20°C)
Causes for Rejection:

Improper collection, gross hemolysis.  Specimen container unlabeled or labeled incorrectly. No date and time of collection on requisition form.
Specimen Preparation:

Within 2 hours of collection, centrifuge. Serum collected in a red top tube should be removed from the cells if testing will be delayed.
Methodology:

 Multiplexing bead immunoassay

Performed:

Clinical Microbiology
Turnaround Time:

Test is performed in batch, once per day, six days a week.
Reference Range:

Positive - Antibody detected. 

Negative - No antibody detected
CPT 4 Code:

83516
Note:

The presence of anti-chromatin antibodies may be useful in the diagnosis of systemic lupus erythematous (SLE) or drug-induced lupus (DIL) and have been reported to be predictive of lupus nephritis.  
Synonyms:

Chromatin Antibody; ENA Antibodies
Patient Preparation :

 Routine venipuncture
Clinical Indication:

Autoimmune disease screening
Effective Date: 04/11/2024
Reviewed By/Date: Williams-Bouyer, Natalie - 03/06/2019
Approved By/Date: Williams-Bouyer, Natalie - 10/08/2024
When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.

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